[Colloquium] Seminar Announcement: NGS Challenge for Algorithms of Eukaryotic Genome Annotation

[Ninfa Mayorga]

**REMINDER**

Computation Institute Presentation 

Speaker: Mark Borodovsky, Georgia Institute of Technology, Atlanta, Georgia
Host: Andrey Rzhetsky 
Date: March 29, 2012 (Thursday)
Time: 1:00 PM - 2:00 PM
Location: University of Chicago, Searle 240A, 5735 S. Ellis Avenue

NGS Challenge for Algorithms of Eukaryotic Genome Annotation 

Abstract:
NGS revolution in sequencing of plant and animal genomes mounted an unprecedented time pressure on genome annotation teams struggling to produce consistent and accurate interpretation of biological "Big Data" streaming from both DNA and RNA levels (RNA-seq). Gene finding plays a fundamental role in bioinformatics. Characterization of protein function, manufacturing DNA microarrays, reconstruction of cellular networks rely on genes and proteins identified by gene finding algorithms. In the talk I will focus on machine learning methods we have recently developed for gene finding in novel eukaryotic genomes. These methods make shortcuts in the pipeline of sequence analysis and interpretation as they do not require accumulation of experimental and/or expert knowledge on the novel genomic data (such as construction of training sets of reliably annotated sequences needed to estimate algorithm parameters). The algorithms have already been used to annotate a number of genomes of fun gal species as well as plant species, such as cucumber, peach, sweet orange and strawberry.

Mark Borodovsky, Director
Center for Bioinformatics and Computational Genomics 
Regents' Professor
Joint Georgia Tech and Emory Wallace H Coulter Department of Biomedical Engineering, 
School of Computational Science and Engineering at Georgia Tech




group: http://opal.gatech.edu/genemark/


Information: Lunch will be provided


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