[Theory] REMINDER: 5/19 TTIC Distinguished Lecture Series: Eran Segal, Weizmann

[Brandie Jones via Theory]

*When:    * Monday, May 19th at* 11 AM CT*



*Where:    *Talk will be given *live, in-person* at

                     TTIC, 6045 S. Kenwood Avenue

                     5th Floor, Room 530


*Virtually:  *via Panopto (Livestream
<https://uchicago.hosted.panopto.com/Panopto/Pages/Viewer.aspx?id=ec72c68c-e173-428b-ac64-b29e0108eb52>
)



*Who:         *Eran Segal, Weizmann

*Title:        *Personalized medicine based on deep human phenotyping

*Abstract:  *Recent technological advances allow large cohorts of human
individuals to be profiled, presenting many challenges and opportunities. I
will present The Human Phenotype Project, a large-scale  (>25,000
participants) deep-phenotype prospective longitudinal cohort and biobank
that we established, aimed at identifying novel molecular markers with
diagnostic, prognostic and therapeutic value, and at developing prediction
models for disease onset and progression. Our deep profiling includes
medical history, lifestyle and nutritional habits, vital signs,
anthropometrics, blood tests, continuous glucose and sleep monitoring, and
molecular profiling of the transcriptome, genetics, gut and oral
microbiome, metabolome and immune system. Our analyses of this data provide
novel insights into potential drivers of obesity, diabetes, and heart
disease, and identify hundreds of novel markers at the microbiome,
metabolite, and immune system level. Foundation AI models that we developed
provide novel representations of the diverse modalities that we measured on
the cohort and achieve state-of-the-art performance in predicting future
onset of disease and trajectories of disease risk factors. Overall, our
predictive models can be translated into personalized disease prevention
and treatment plans, and to the development of new therapeutic modalities
based on metabolites and the microbiome.

*Bio:*  Eran Segal is a computational biologist professor at the Weizmann
Institute of Science. He leads a multi-disciplinary team of computational
biologists and experimental scientists working in the area of Computational
and Systems biology. Focuses on Nutrition, Genetics, Microbiome, and Gene
Regulation and their effect on health and disease. His lab aims to develop
personalized nutrition and personalized medicine using machine learning,
computational biology, probabilistic modeling, and analysis of
heterogeneous high-throughput genomic and clinical data.

Hos*t: Nati Srebro <nati at ttic.edu>*

--
*Brandie Jones *
*Executive **Administrative Assistant*
Toyota Technological Institute
6045 S. Kenwood Avenue
Chicago, IL  60637
www.ttic.edu
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mailman.cs.uchicago.edu/pipermail/theory/attachments/20250516/bd40b6c6/attachment-0001.html>