<div dir="ltr"><div dir="ltr"><div><div class="gmail_default" style="font-family:georgia,serif;font-size:small;color:rgb(0,0,0)"><div><div class="gmail_default"><font face="georgia, serif" color="#000000"><b><font style="vertical-align:inherit"><font style="vertical-align:inherit">When:    </font></font></b><font style="vertical-align:inherit"><font style="vertical-align:inherit"> Monday, May 19th at<b><span style="background-color:rgb(255,255,0)"> 11</span><span style="background-color:rgb(255,255,0)"> AM CT</span></b></font></font></font></div><div><div><p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="georgia, serif" color="#000000"> </font></p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="georgia, serif" color="#000000"><font style="vertical-align:inherit"><font style="vertical-align:inherit"><b>Where:    </b><span class="gmail_default"><b></b></span><span class="gmail_default">T</span></font></font>alk will be given <font style="font-weight:bold"><u style="background-color:rgb(255,255,0)">live, in-person</u></font><font style="font-weight:bold"> </font>at</font></p><p class="MsoNormal" style="margin:0in;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font color="#000000" face="georgia, serif">                     TTIC, 6045 S. Kenwood Avenue</font></p><p class="MsoNormal" style="margin:0in;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font color="#000000" face="georgia, serif">                     5th Floor, Room 530<b> </b></font></p><p class="MsoNormal" style="margin:0in;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font color="#000000" face="georgia, serif"><b><br></b></font></p><p class="MsoNormal" style="margin:0in;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="georgia, serif" color="#000000"><span class="gmail_default"><b>Virtually:  </b>via Panopto<b> </b>(<a href="https://uchicago.hosted.panopto.com/Panopto/Pages/Viewer.aspx?id=ec72c68c-e173-428b-ac64-b29e0108eb52" target="_blank">Livestream</a>) </span><b><br></b></font></p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="georgia, serif" color="#000000"> </font></p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="georgia, serif" color="#000000"><b><font style="vertical-align:inherit"><font style="vertical-align:inherit">Who:      <span class="gmail_default"></span>   </font></font></b>Eran Segal, Weizmann</font></p></div><div><b><font face="georgia, serif" color="#000000"><br></font></b></div><div><font face="georgia, serif" color="#000000"><b>Title:        </b>Personalized medicine based on deep human phenotyping</font></div><div><p></p><div><font face="georgia, serif" color="#000000"><b>Abstract:  </b>Recent technological advances allow large cohorts of human individuals to be profiled, presenting many challenges and opportunities. I will present The Human Phenotype Project, a large-scale  (>25,000 participants) deep-p<span class="gmail_default"></span>henotype prospective longitudinal cohort and biobank that we established, aimed at identifying novel molecular markers with diagnostic, prognostic and therapeutic value, and at developing prediction models for disease onset and progression. Our deep profiling includes medical history, lifestyle and nutritional habits, vital signs, anthropometrics, blood tests, continuous glucose and sleep monitoring, and molecular profiling of the transcriptome, genetics, gut and oral microbiome, metabolome and immune system. Our analyses of this data provide novel insights into potential drivers of obesity, diabetes, and heart disease, and identify hundreds of novel markers at the microbiome, metabolite, and immune system level. Foundation AI models that we developed provide novel representations of the diverse modalities that we measured on the cohort and achieve state-of-the-art performance in predicting future onset of disease and trajectories of disease risk factors. Overall, our predictive models can be translated into personalized disease prevention and treatment plans, and to the development of new therapeutic modalities based on metabolites and the microbiome.</font></div></div><div><font face="georgia, serif" color="#000000"><br></font><div><font face="georgia, serif" color="#000000"><b><span class="gmail_default"></span>Bio:</b>  Eran Segal is a computational biologist professor at the Weizmann Institute of Science. He leads a multi-disciplinary team of computational biologists and experimental scientists working in the area of Computational and Systems biology. Focuses on Nutrition, Genetics, Microbiome, and Gene Regulation and their effect on health and disease. His lab aims to develop personalized nutrition and personalized medicine using machine learning, computational biology, probabilistic modeling, and analysis of heterogeneous high-throughput genomic and clinical data.</font></div><div><font face="georgia, serif" color="#000000"><br></font></div><div><p style="box-sizing:border-box;border-radius:0px;margin:0px 0px 10px"><font face="georgia, serif" color="#000000"><span style="box-sizing:border-box;border-radius:0px;font-weight:700">Hos</span><b><span style="box-sizing:border-box;border-radius:0px">t:<span class="gmail_default"> <a href="mailto:nati@ttic.edu" target="_blank">Nati Srebro</a></span></span></b></font></p></div></div></div></div><div><br></div><span class="gmail_signature_prefix">--</span><br><div dir="ltr" class="gmail_signature"><div dir="ltr"><b style="color:rgb(34,34,34);font-family:Arial,Helvetica,sans-serif"><font color="#3d85c6">Brandie Jones </font></b><div style="color:rgb(34,34,34);font-family:Arial,Helvetica,sans-serif"><div><div><font color="#3d85c6"><b><i>Executive </i></b></font><b style="color:rgb(61,133,198)"><i>Administrative Assistant</i></b></div></div><div><font color="#3d85c6">Toyota Technological Institute</font></div><div><font color="#3d85c6">6045 S. Kenwood Avenue</font></div><div><font color="#3d85c6">Chicago, IL  60637</font></div></div><div style="color:rgb(34,34,34);font-family:Arial,Helvetica,sans-serif"><font color="#3d85c6"><a href="http://www.ttic.edu/" target="_blank">www.ttic.edu</a> </font></div><br></div></div></div></div></div>
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