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<span class="" style="font-family: Calibri, Helvetica, sans-serif; font-size: 11pt; line-height: 1.2;">This is an announc</span><span class="" style="font-family: Calibri, Helvetica, sans-serif; font-size: 11pt; line-height: 1.2;">ement of <span class="outlook-search-highlight"><span class="outlook-search-highlight">Priyanka</span></span> Setty's
MS Presentation</span></div>
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<span class="" style="font-family: Calibri, Helvetica, sans-serif; font-size: 11pt; line-height: 1.2;">===============================================</span></div>
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<span class="" style="font-family: Calibri, Helvetica, sans-serif; font-size: 11pt; line-height: 1.2;">Candidate: <span class="outlook-search-highlight"><span class="outlook-search-highlight">Priyanka</span></span> Setty</span></div>
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<span class="" style="font-family: Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0); line-height: 1.2;">Date: Thursday, March 28, 2024</span></div>
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<span class="" style="font-family: Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0); line-height: 1.2;">Time: 10 am CT</span></div>
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<span class="" style="font-family: Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0); line-height: 1.2;">Location: JCL 298</span></div>
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<span class="" style="font-family: Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0); line-height: 1.2;">Title: AMP Architect: A Multi-Agent AI Framework for Antimicrobial Peptide Design</span></div>
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<span class="" style="font-family: Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0); line-height: 1.2;">Abstract: In response to the escalating crisis of antimicrobial resistance (AMR), which accounts for an estimated 4.95 million deaths
globally each year, we propose to develop a self-driving laboratory for designing antimicrobial peptides (AMPs). AMPs are small, naturally occurring molecules recognized for their broad-spectrum antibacterial activity and unique mechanisms of action, positioning
them as promising candidates for the development of new therapeutics against drug-resistant bacteria. </span></div>
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<span class="" style="font-family: Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0); line-height: 1.2;">Conventional in vitro and in vivo experimental assays, while considered the benchmark for AMP discovery and validation, are limited by
the immense combinatorial complexity of potential AMP sequences. For instance, designing, a peptide of merely 20 amino acids in length presents an astronomical 20^20 〖^〗possible combinations, rendering traditional methods insufficient. To autonomously navigate
this vast space, we propose the development of AMP Architect, a novel multi-agent AI framework specifically designed to generate, screen, and validate potential AMP candidates. This system integrates and analyzes data from diverse sources, identifies peptides
with specific functions, and predicts their efficacy and safety profiles through a combined computational and experimental approach. </span></div>
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<span class="" style="font-family: Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0); line-height: 1.2;">A core component of this self-driving laboratory is the integration of generative AI with state-of-the-art robotic platforms, which autonomously
execute growth assays to assess the antimicrobial efficacy of AMPs. This approach not only expedites the discovery process but also enhances the precision of screening high-potential AMP candidates. By amalgamating these technological advancements within the
multi-agent framework, we envision such a multi-agent workflow will enable a transformative step in our ability to combat AMR and reduce the global health burden it currently imposes.</span></div>
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<span class="" style="font-family: Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0); line-height: 1.2;">Advisors: Ian Foster</span></div>
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<span class="" style="font-family: Calibri, Helvetica, sans-serif; font-size: 11pt; color: rgb(0, 0, 0); line-height: 1.2;">Committee Members: Rick Stevens, Arvind Ramanathan, and Ian Foster</span></div>
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