<div dir="ltr"><div dir="ltr"><div class="gmail_default" style="font-size:small"><div class="gmail_default"><div class="gmail_default"><font face="arial, sans-serif"><font style="color:rgb(0,0,0);vertical-align:inherit"><font style="vertical-align:inherit"><b>When:</b> </font></font><font style="vertical-align:inherit"><font style="vertical-align:inherit"><font style="color:rgb(0,0,0)"> Monday, April 24</font><span class="gmail_default" style="color:rgb(0,0,0)">, 2023</span><font style="color:rgb(0,0,0)"> at</font><b style="color:rgb(0,0,0)"> <u>11:30</u></b><b><u><font color="#000000"> a</font></u></b><b><u><font color="#000000">m CT</font></u><font color="#000000"> </font></b></font></font><br></font></div><div class="gmail_default"><p style="color:rgb(80,0,80);font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;line-height:normal;margin:0px"><b style="font-family:arial,sans-serif"><font color="#500050"><br></font></b></p><p style="color:rgb(80,0,80);font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;line-height:normal;margin:0px"><b style="font-family:arial,sans-serif"><font color="#500050">Where: </font></b><font color="#000000" style="font-family:arial,sans-serif">Talk will be given </font><font color="#000000" style="font-family:arial,sans-serif;font-weight:bold"><u>live, in-person</u></font><font style="font-family:arial,sans-serif;font-weight:bold"> </font><span style="font-family:arial,sans-serif">at</span><br></p><p class="MsoNormal" style="margin:0in;color:rgb(80,0,80);line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><font color="#500050"> </font><font color="#000000"> TTIC, 6045 S. Kenwood Avenue</font></font></p><p class="MsoNormal" style="margin:0in;color:rgb(80,0,80);line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif" color="#000000"> 5th Floor, Room 530<b> </b></font></p><p class="MsoNormal" style="margin:0in;color:rgb(80,0,80);line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><b><span style="color:black"><br></span></b></font></p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;color:rgb(80,0,80);line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><b style="color:rgb(60,64,67);letter-spacing:0.2px;white-space:pre-wrap">Virtually:</b><span style="color:rgb(60,64,67);letter-spacing:0.2px;white-space:pre-wrap"> <i>via </i>Panopto </span>(<b><a href="https://uchicago.hosted.panopto.com/Panopto/Pages/Viewer.aspx?id=d09c990d-316a-4fba-9884-afe80148e235" target="_blank">livestream</a></b><span style="color:rgb(60,64,67);letter-spacing:0.2px;white-space:pre-wrap">)</span><br></font></p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;color:rgb(80,0,80);line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:rgb(60,64,67);letter-spacing:0.2px;white-space:pre-wrap"> <font size="1"> *Access limited to TTIC/UChicago (see info below)</font></span></font></p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;color:rgb(80,0,80);line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:rgb(60,64,67);letter-spacing:0.2px;white-space:pre-wrap"><br></span></font></p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;color:rgb(80,0,80);line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font style="font-family:arial,sans-serif;vertical-align:inherit"><font style="vertical-align:inherit"><b>Who: </b> <font color="#500050"> </font><font color="#000000"><font color="#500050"> </font></font></font></font><span style="color:rgb(34,34,34)"><font face="tahoma, sans-serif">Aleksandrina Goeva, Broad Institute of MIT and Harvard</font></span></p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;color:rgb(80,0,80);line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><span style="color:rgb(34,34,34)"><br></span></p><div class="MsoNormal" align="center" style="margin:0in 0in 8pt;color:rgb(80,0,80);text-align:center;line-height:15.6933px"><hr size="2" width="100%" align="center"></div><div><div><span id="m_-7622701669742356547m_-6967680496673197251m_8731442605182037865m_-6294525540622960617gmail-docs-internal-guid-fa76653a-7fff-1406-a32b-0d9b384fe884" style="color:rgb(0,0,0)"><font face="arial, sans-serif"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><b style="white-space:pre-wrap">Title:</b><span style="white-space:pre-wrap"> </span><span style="color:rgb(34,34,34)">Machine Learning Methods for Inferring Changes in Cells Across Space, Time, Health and Disease</span><br></p></font></span></div><div><span id="m_-7622701669742356547m_-6967680496673197251m_8731442605182037865m_-6294525540622960617gmail-docs-internal-guid-fa76653a-7fff-1406-a32b-0d9b384fe884" style="color:rgb(0,0,0)"><font face="arial, sans-serif"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-variant-numeric:normal;font-variant-alternates:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><br></span></p></font></span></div><div><span id="m_-7622701669742356547m_-6967680496673197251m_8731442605182037865m_-6294525540622960617gmail-docs-internal-guid-fa76653a-7fff-1406-a32b-0d9b384fe884" style="color:rgb(0,0,0)"><font face="arial, sans-serif"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><b style="white-space:pre-wrap">Abstract:</b><span style="white-space:pre-wrap"> The dream of generations of scientists and physicians, to be able to ask any question about cellular function or tissue organization, is becoming reality through single cell and tissue profiling technologies. However, our ability to render these technological advancements into actionable information in research or in the clinic necessitates the development of rigorous, efficient, robust, testable, and interpretable analytical methods. In this talk, I will provide a survey of my contributions to the fields of molecular cell and tissue biology in the development of (1) interpretable models of spatial transcriptomics data leveraging prior domain knowledge from annotated single-cell atlases, (2) principled statistical and machine learning methods for discovering transcriptional changes across conditions, and (3) systems biology approaches and hypothesis testing frameworks for modeling cell-cell communication.</span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="white-space:pre-wrap"><br></span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap"><b>Bio:</b> </span>Aleksandrina Goeva<span style="font-weight:bold"> </span>is a Postdoctoral Fellow in the Macosko Lab at the Stanley Center for Psychiatric Research within the Broad Institute of MIT and Harvard. She received her PhD in Statistics at Boston University, where she worked with Henry Lam and Eric Kolaczyk on complexity penalized methods for structured and unstructured data. During her postdoc, Aleksandrina has developed a deep interest in complex biological systems, for which we typically have only an incomplete and noisy set of measurements, and for the impact that expanding our knowledge of basic biological mechanisms can have on improving human health. Her current research is focused on ill-posed inverse problems in biology, where she combines domain expert knowledge with modeling approaches applied to single-cell RNA-seq and spatial transcriptomics data to answer questions about the mechanisms of interaction between cells and the function of tissues in health and disease. In addition to striving to gain useful biological insights, Aleksandrina also works on theoretical problems in statistics that arise from her applied work. Aleksandrina has extensive experience in math, stats, and science education centered around her passion for conveying complex concepts in simple and accurate terms. She also has extensive leadership experience in building enduring structured environments that foster connections within and across fields and gather large local and global scientific communities illustrated by her service as a co-chair of the Models, Inference & Algorithms seminar series at the Broad Institute, as an Assistant Editor at the Harvard Data Science Review journal, and as an organizer of the Learning Meaningful Representations of Life workshop at NeurIPS. <span style="white-space:pre-wrap"><br></span></p></font></span></div></div><div><div><div><font color="#000000" face="arial, sans-serif"><b><br></b></font></div><div><b style="color:rgb(0,0,0);font-family:arial,sans-serif">Host: </b><a href="mailto:j3xu@ttic.edu" target="_blank" style="font-family:arial,sans-serif">Jinbo Xu</a><br></div></div></div><br></div><div class="gmail_default"><br></div><div class="gmail_default"><font size="1"><font color="#0000ff">*</font>Access to this livestream is limited to <b>TTIC / UChicago</b> (press panopto link and login to your UChicago account). </font><br></div></div><div><div dir="ltr"><div dir="ltr"><br></div><div dir="ltr"><br></div><div dir="ltr"><br></div></div></div></div><div><div dir="ltr" class="gmail_signature"><div dir="ltr"><div><span style="font-family:arial,helvetica,sans-serif;font-size:x-small">Mary C. Marre</span><br></div><div><div><font face="arial, helvetica, sans-serif" size="1">Faculty Administrative Support</font></div><div><i><font face="arial, helvetica, sans-serif" color="#3d85c6" size="1"><b>Toyota Technological Institute</b></font></i></div><div><i><font face="arial, helvetica, sans-serif" color="#3d85c6" size="1">6045 S. Kenwood Avenue, Rm 517</font></i></div><div><font size="1"><i><font face="arial, helvetica, sans-serif" color="#3d85c6">Chicago, IL 60637</font></i><br></font></div><div><font size="1"><i><font face="arial, helvetica, sans-serif" color="#3d85c6">773-834-1757</font></i></font></div><div><b><i><a href="mailto:mmarre@ttic.edu" target="_blank"><font face="arial, helvetica, sans-serif" size="1">mmarre@ttic.edu</font></a></i></b></div></div></div></div></div><br></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Tue, Apr 18, 2023 at 4:27 PM Mary Marre <<a href="mailto:mmarre@ttic.edu">mmarre@ttic.edu</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><div dir="ltr"><div><div><div style="font-size:small"><font face="arial, sans-serif"><font style="color:rgb(0,0,0);vertical-align:inherit"><font style="vertical-align:inherit"><b>When:</b> </font></font><font style="vertical-align:inherit"><font style="vertical-align:inherit"><font style="color:rgb(0,0,0)"> Monday, April 24</font><span class="gmail_default" style="color:rgb(0,0,0)">, 2023</span><font style="color:rgb(0,0,0)"> at</font><b style="color:rgb(0,0,0)"> <u style="background-color:rgb(255,255,255)">11:30</u></b><span style="background-color:rgb(255,255,255)"><b><u><font color="#000000"> a</font></u></b><b><u><font color="#000000">m CT</font></u><font color="#000000"> </font></b></span></font></font><br></font></div><div><p style="font-size:small;color:rgb(80,0,80);font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;line-height:normal;margin:0px"><b style="font-family:arial,sans-serif"><font color="#500050"><br></font></b></p><p style="font-size:small;color:rgb(80,0,80);font-variant-numeric:normal;font-variant-east-asian:normal;font-stretch:normal;line-height:normal;margin:0px"><b style="font-family:arial,sans-serif"><font color="#500050">Where: </font></b><font color="#000000" style="font-family:arial,sans-serif"><span>Talk</span> will be given </font><font color="#000000" style="font-family:arial,sans-serif;font-weight:bold"><u>live, in-person</u></font><font style="font-family:arial,sans-serif;font-weight:bold"> </font><span style="font-family:arial,sans-serif">at</span><br></p><p class="MsoNormal" style="font-size:small;margin:0in;color:rgb(80,0,80);line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><font color="#500050"> </font><font color="#000000"> <span>TTIC</span>, 6045 S. Kenwood Avenue</font></font></p><p class="MsoNormal" style="font-size:small;margin:0in;color:rgb(80,0,80);line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif" color="#000000"> 5th Floor, Room 530<b> </b></font></p><p class="MsoNormal" style="font-size:small;margin:0in;color:rgb(80,0,80);line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><b><span style="color:black"><br></span></b></font></p><p class="MsoNormal" style="font-size:small;margin:0in 0in 0.0001pt;color:rgb(80,0,80);line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><b style="color:rgb(60,64,67);letter-spacing:0.2px;white-space:pre-wrap">Virtually:</b><span style="color:rgb(60,64,67);letter-spacing:0.2px;white-space:pre-wrap"> <i>via </i>Panopto </span>(<b><a href="https://uchicago.hosted.panopto.com/Panopto/Pages/Viewer.aspx?id=d09c990d-316a-4fba-9884-afe80148e235" target="_blank">livestream</a></b><span style="color:rgb(60,64,67);letter-spacing:0.2px;white-space:pre-wrap">)</span><br></font></p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;color:rgb(80,0,80);line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:rgb(60,64,67);letter-spacing:0.2px;white-space:pre-wrap"> <font size="1"> *Access limited to TTIC/UChicago (see info below)</font></span></font></p><p class="MsoNormal" style="font-size:small;margin:0in 0in 0.0001pt;color:rgb(80,0,80);line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:rgb(60,64,67);letter-spacing:0.2px;white-space:pre-wrap"><br></span></font></p><p class="MsoNormal" style="margin:0in 0in 0.0001pt;color:rgb(80,0,80);line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font style="font-size:small;font-family:arial,sans-serif;vertical-align:inherit"><font style="vertical-align:inherit"><b>Who: </b> <font color="#500050"> </font><font color="#000000"><font color="#500050"> </font></font></font></font><span style="color:rgb(34,34,34)"><font face="tahoma, sans-serif">Aleksandrina Goeva, Broad Institute of MIT and Harvard</font></span></p><p class="MsoNormal" style="font-size:small;margin:0in 0in 0.0001pt;color:rgb(80,0,80);line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><span style="color:rgb(34,34,34)"><br></span></p><div class="MsoNormal" align="center" style="font-size:small;margin:0in 0in 8pt;color:rgb(80,0,80);text-align:center;line-height:15.6933px"><hr size="2" width="100%" align="center"></div><div><div><span id="m_-7622701669742356547m_-6967680496673197251m_8731442605182037865m_-6294525540622960617gmail-docs-internal-guid-fa76653a-7fff-1406-a32b-0d9b384fe884" style="color:rgb(0,0,0)"><font face="arial, sans-serif"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><b style="font-size:small;white-space:pre-wrap">Title:</b><span style="font-size:small;white-space:pre-wrap"> </span><span style="color:rgb(34,34,34)">Machine Learning Methods for Inferring Changes in Cells Across Space, Time, Health and Disease</span><br></p></font></span></div><div style="font-size:small"><span id="m_-7622701669742356547m_-6967680496673197251m_8731442605182037865m_-6294525540622960617gmail-docs-internal-guid-fa76653a-7fff-1406-a32b-0d9b384fe884" style="color:rgb(0,0,0)"><font face="arial, sans-serif"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-variant-numeric:normal;font-variant-alternates:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><br></span></p></font></span></div><div style="font-size:small"><span id="m_-7622701669742356547m_-6967680496673197251m_8731442605182037865m_-6294525540622960617gmail-docs-internal-guid-fa76653a-7fff-1406-a32b-0d9b384fe884" style="color:rgb(0,0,0)"><font face="arial, sans-serif"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><b style="white-space:pre-wrap">Abstract:</b><span style="white-space:pre-wrap"> The dream of generations of scientists and physicians, to be able to ask any question about cellular function or tissue organization, is becoming reality through single cell and tissue profiling technologies. However, our ability to render these technological advancements into actionable information in research or in the clinic necessitates the development of rigorous, efficient, robust, testable, and interpretable analytical methods. In this talk, I will provide a survey of my contributions to the fields of molecular cell and tissue biology in the development of (1) interpretable models of spatial transcriptomics data leveraging prior domain knowledge from annotated single-cell atlases, (2) principled statistical and machine learning methods for discovering transcriptional changes across conditions, and (3) systems biology approaches and hypothesis testing frameworks for modeling cell-cell communication.</span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="white-space:pre-wrap"><br></span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap"><b>Bio:</b> </span>Aleksandrina Goeva<span style="font-weight:bold"> </span>is a Postdoctoral Fellow in the Macosko Lab at the Stanley Center for Psychiatric Research within the Broad Institute of MIT and Harvard. She received her PhD in Statistics at Boston University, where she worked with Henry Lam and Eric Kolaczyk on complexity penalized methods for structured and unstructured data. During her postdoc, Aleksandrina has developed a deep interest in complex biological systems, for which we typically have only an incomplete and noisy set of measurements, and for the impact that expanding our knowledge of basic biological mechanisms can have on improving human health. Her current research is focused on ill-posed inverse problems in biology, where she combines domain expert knowledge with modeling approaches applied to single-cell RNA-seq and spatial transcriptomics data to answer questions about the mechanisms of interaction between cells and the function of tissues in health and disease. In addition to striving to gain useful biological insights, Aleksandrina also works on theoretical problems in statistics that arise from her applied work. Aleksandrina has extensive experience in math, stats, and science education centered around her passion for conveying complex concepts in simple and accurate terms. She also has extensive leadership experience in building enduring structured environments that foster connections within and across fields and gather large local and global scientific communities illustrated by her service as a co-chair of the Models, Inference & Algorithms seminar series at the Broad Institute, as an Assistant Editor at the Harvard Data Science Review journal, and as an organizer of the Learning Meaningful Representations of Life workshop at NeurIPS. <span style="white-space:pre-wrap"><br></span></p></font></span></div></div><div style="font-size:small"><div><div><font color="#000000" face="arial, sans-serif"><b><br></b></font></div><div><b style="color:rgb(0,0,0);font-family:arial,sans-serif">Host: </b><a href="mailto:j3xu@ttic.edu" style="font-family:arial,sans-serif" target="_blank">Jinbo Xu</a><br></div></div></div><br></div><div><br></div><div><font size="1"><font color="#0000ff">*</font>Access to this livestream is limited to <b><span>TTIC</span> / UChicago</b> (press panopto link and login to your UChicago account). </font><br></div></div><div style="font-size:small"><div dir="ltr"><div dir="ltr"><br></div><div dir="ltr"><br></div><div dir="ltr"><br></div><div dir="ltr"><br></div></div></div></div><div><div dir="ltr"><div dir="ltr"><div><span style="font-family:arial,helvetica,sans-serif;font-size:x-small">Mary C. Marre</span><br></div><div><div><font face="arial, helvetica, sans-serif" size="1">Faculty Administrative Support</font></div><div><i><font face="arial, helvetica, sans-serif" color="#3d85c6" size="1"><b>Toyota Technological Institute</b></font></i></div><div><i><font face="arial, helvetica, sans-serif" color="#3d85c6" size="1">6045 S. Kenwood Avenue, Rm 517</font></i></div><div><font size="1"><i><font face="arial, helvetica, sans-serif" color="#3d85c6">Chicago, IL 60637</font></i><br></font></div><div><font size="1"><i><font face="arial, helvetica, sans-serif" color="#3d85c6">773-834-1757</font></i></font></div><div><b><i><a href="mailto:mmarre@ttic.edu" target="_blank"><font face="arial, helvetica, sans-serif" size="1">mmarre@ttic.edu</font></a></i></b></div></div></div></div></div></div>
</blockquote></div></div>