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<b style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial">

<div class="gmail_default" style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;text-decoration-style:initial;text-decoration-color:initial"><font color="#000000" face="arial, helvetica, sans-serif" style="">When: <span style="font-weight:400">    Monday, February 12th </span><span class="gmail-m_1517372298344856049gmail-m_491069367152086750gmail-m_-8327640324523575189gmail-m_2420618808463760418gmail-m_7960197898027616883gmail-m_8692226636264124041gmail-m_2794822896869921223gmail-m_7508998950622620526gmail-m_-7153355664495542534gmail-il" style="font-weight:400">at</span><span style="font-weight:400"> </span><b style="background-color:rgb(255,255,255)">10:30 am</b></font></div><div class="gmail_default" style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;text-decoration-style:initial;text-decoration-color:initial"><font color="#000000" face="arial, helvetica, sans-serif"><br></font></div><div class="gmail_default" style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;text-decoration-style:initial;text-decoration-color:initial"><font color="#000000" face="arial, helvetica, sans-serif" style="">Where:<span style="font-weight:400">    </span><span class="gmail-m_1517372298344856049gmail-m_491069367152086750gmail-m_-8327640324523575189gmail-m_2420618808463760418gmail-m_7960197898027616883gmail-m_8692226636264124041gmail-m_2794822896869921223gmail-m_7508998950622620526gmail-m_-7153355664495542534gmail-m_8421504075585210435gmail-m_3262824545120381495gmail-m_-1141671822915777344gmail-m_-7219251726624328345gmail-m_-8588148075564318222gmail-m_-8767966813928691312gmail-m_-1542318334608687154gmail-m_5717104778280916634gmail-m_4845490158781220632gmail-m_5124567205141626540gmail-m_3209361100497750746gmail-m_2953668934074478317gmail-m_-3155518689668024534m_9067904842688472155gmail-m_3071693547520408192gmail-il" style="font-weight:400"><span class="gmail-m_1517372298344856049gmail-m_491069367152086750gmail-m_-8327640324523575189gmail-m_2420618808463760418gmail-m_7960197898027616883gmail-m_8692226636264124041gmail-m_2794822896869921223gmail-m_7508998950622620526gmail-m_-7153355664495542534gmail-il">TTIC</span></span><span style="font-weight:400">, 6045 S Kenwood Avenue, 5th Floor, Room 526</span></font></div><div class="gmail_default" style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;text-decoration-style:initial;text-decoration-color:initial"><br></div><div style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;text-decoration-style:initial;text-decoration-color:initial"><font color="#000000" style="font-size:12.8px"><font face="arial, helvetica, sans-serif" style="">Who:<span style="font-weight:400">       </span></font></font><font color="#000000" face="arial, helvetica, sans-serif" style="font-weight:400"><span style="font-size:12.8px">Michael Yu, UC San Diego</span></font></div><br class="gmail-Apple-interchange-newline">

<br class="gmail-Apple-interchange-newline">Title</b><span style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline">:       Hierarchical Modeling of Biological Systems</span><br style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial"><br style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial"><b style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial">Abstract</b><span style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline">: Biological systems are hierarchically organized at multiple scales:  changes to genes and proteins (1-10nm) affect the functions of protein complexes and cellular processes (10-100nm), which ultimately alter the behaviors of cells (1-10um) and individuals (>1m). While some of this hierarchical structure is known by manual curation, I will show how it can also be discovered in a data-driven manner by integrating millions of experimental results, revealing new biology unknown to even experts. I will also discuss ongoing algorithmic challenges in hierarchical modeling of biological systems and how they apply to other domains like natural language. Next, I will show how hierarchical structure can enable more interpretable machine learning models of complex behaviors like cell growth.</span><br style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial"><br style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial"><b style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial">Bio</b><span style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline">:<span> </span></span><span class="gmail-il" style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial">Michael</span><span style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline"><span> </span></span><span class="gmail-il" style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial">Yu</span><span style="color:rgb(34,34,34);font-family:arial,sans-serif;font-size:12.8px;font-style:normal;font-variant-ligatures:normal;font-variant-caps:normal;font-weight:400;letter-spacing:normal;text-align:start;text-indent:0px;text-transform:none;white-space:normal;word-spacing:0px;background-color:rgb(255,255,255);text-decoration-style:initial;text-decoration-color:initial;float:none;display:inline"><span> </span>recently finished his PhD in bioinformatics at UC San Diego, where he developed new methods in network biology with his advisor Trey Ideker and was a fellow at the San Diego Center for Systems Biology. Previously, he received his B.S. and M.Eng. in computer science at MIT, where he studied comparative genomics and RNA structure under the direction of Bonnie Berger.</span> <div><br><div><br></div><div><b>Host:</b>  <a href="mailto:j3xu@ttic.edu">Jinbo Xu   </a></div><div><br></div><div><br></div><div><br clear="all"><div><div class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><font face="arial, helvetica, sans-serif">Mary C. Marre</font><div><font face="arial, helvetica, sans-serif">Administrative Assistant</font></div><div><i><font face="arial, helvetica, sans-serif" color="#3d85c6"><b>Toyota Technological Institute</b></font></i></div><div><i><font face="arial, helvetica, sans-serif" color="#3d85c6">6045 S. Kenwood Avenue</font></i></div><div><i><font face="arial, helvetica, sans-serif" color="#3d85c6">Room 504</font></i></div><div><i><font face="arial, helvetica, sans-serif" color="#3d85c6">Chicago, IL  60637</font></i></div><div><i><font face="arial, helvetica, sans-serif">p:(773) 834-1757</font></i></div><div><i><font face="arial, helvetica, sans-serif">f: (773) 357-6970</font></i></div><div><b><i><a href="mailto:mmarre@ttic.edu" target="_blank"><font face="arial, helvetica, sans-serif">mmarre@ttic.edu</font></a></i></b></div></div></div></div></div></div></div></div></div></div>
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