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<div class=Section1>
<p class=MsoNormal><font size=2 color=navy face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:navy'><o:p> </o:p></span></font></p>
<div>
<p class=MsoNormal><b style='mso-bidi-font-weight:normal'><font size=3
face="Times New Roman"><span style='font-size:12.0pt;mso-fareast-language:JA;
font-weight:bold;mso-bidi-font-weight:normal'>Reminder<span class=GramE>!!</span><o:p></o:p></span></font></b></p>
</div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Guest Speaker<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Presented by: <st1:City w:st="on">Toyota</st1:City> Technological
Institute at <st1:place w:st="on"><st1:City w:st="on">Chicago</st1:City></st1:place><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal><b style='mso-bidi-font-weight:normal'><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-weight:bold;
mso-bidi-font-weight:normal'>Speaker: Sorin Draghici<o:p></o:p></span></font></b></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Speaker’s home page: <a
href="http://vortex.cs.wayne.edu/sorin/index.htm">http://vortex.cs.wayne.edu/sorin/index.htm</a><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal><b style='mso-bidi-font-weight:normal'><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-weight:bold;
mso-bidi-font-weight:normal'>Date: Tuesday, May 1, 2007<o:p></o:p></span></font></b></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Time: 10:00<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Location: TTI-C Conference room<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal><b style='mso-bidi-font-weight:normal'><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-weight:bold;
mso-bidi-font-weight:normal'>Title:</span></font></b> A systems biology
approach to pathway analysis<o:p></o:p></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal><b style='mso-bidi-font-weight:normal'><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-weight:bold;
mso-bidi-font-weight:normal'>Abstract:<o:p></o:p></span></font></b></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>A common challenge in the analysis of genomics data is trying to
understand the underlying phenomenon in the context of all complex interactions
taking place on various signaling pathways.<span
style='mso-spacerun:yes'> </span>A statistical approach using various
models is universally used to identify the most relevant pathways in a given
experiment.<span style='mso-spacerun:yes'> </span>In this talk, we show
that despite its general adoption, this statistical analysis is unsatisfactory,
and can often provide incorrect results.<span style='mso-spacerun:yes'>
</span>We discuss how and why the limited numerical nature of this approach
makes it ill suited to cope with the complex interactions and dependencies that
characterize living organisms. Using a systems biology approach, we developed a
more powerful impact analysis that extends the classical statistical approach
by incorporating a number of crucial biological factors such as the magnitude
of the expression change for each gene, the type and the position of the genes
in the given pathways, the interactions between them, etc<span class=GramE>. </span>To
the best of our knowledge, none of the other approaches currently used for
pathway analysis is able to integrate these factors in a coherent model.<span
style='mso-spacerun:yes'> </span>Notably, the novel integrated model we
propose is fully coherent with the classical approach. When the limitations of
the classical approach are forcefully imposed (e.g., ignoring the magnitude of
the measured expression changes or ignoring the regulatory interactions between
genes), the impact analysis r<st1:PersonName w:st="on">edu</st1:PersonName>ces
to the classical approach and yields exactly the same results.<span
style='mso-spacerun:yes'> </span>On several illustrative data sets, the
classical analysis produces both false positives and false negatives while the
impact analysis provides biologically meaningful results.<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>If you have any questions or would like to meet the speaker, please
contact Ponda Barnes at <a href="mailto:pondabarnes@tti-c.org">pondabarnes@tti-c.org</a><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>For future TTI-C talks and events please go to <a
href="http://ttic.uchicago.edu/cal/month.php">http://ttic.uchicago.edu/cal/month.php</a><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
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