[Colloquium] REMINDER: 2/22 Talks at TTIC: Shahin Mohammadi, Purdue

[Mary Marre via Colloquium]

When:     Wednesday, February 22nd at 11:00 am

Where:    TTIC, 6045 S Kenwood Avenue, 5th Floor, Room 526

Who:       Shahin Mohammadi, Purdue


Title:     Take ACTION to Characterize the Functional Identity of Single
Cells

Abstract:
Single-cell transcriptomic data has the potential to radically redefine our
view of cell type identity. Cells that were previously believed to be
homogeneous are now clearly distinguishable in terms of their expression
phenotype. Methods for automatically characterizing the functional identity
of cells, and their associated properties, can be used to uncover processes
involved in lineage differentiation as well as sub-typing cancer cells.
They can also be used to suggest personalized therapies based on molecular
signatures associated with pathology.

In this talk, I will introduce a method that I have recently developed,
called Archetypal-analysis for cell type identificaTION (ACTION), to infer
the functional identity of cells from their transcriptional profile,
classify them based on their principal functions, and reconstruct
regulatory networks that are responsible for mediating their identity.
Results from using ACTION to sub-type cancer cells in Melanoma patients
reveal novel biomarkers along with their underlying regulatory networks.


Host: Jinbo Xu <jinbo.xu at gmail.com>



Mary C. Marre
Administrative Assistant
*Toyota Technological Institute*
*6045 S. Kenwood Avenue*
*Room 504*
*Chicago, IL  60637*
*p:(773) 834-1757*
*f: (773) 357-6970*
*mmarre at ttic.edu <mmarre at ttic.edu>*

On Wed, Feb 15, 2017 at 7:16 PM, Mary Marre <mmarre at ttic.edu> wrote:

> When:     Wednesday, February 22nd at 11:00 am
>
> Where:    TTIC, 6045 S Kenwood Avenue, 5th Floor, Room 526
>
> Who:       Shahin Mohammadi, Purdue
>
>
> Title:     Take ACTION to Characterize the Functional Identity of Single
> Cells
>
> Abstract:
> Single-cell transcriptomic data has the potential to radically redefine
> our view of cell type identity. Cells that were previously believed to be
> homogeneous are now clearly distinguishable in terms of their expression
> phenotype. Methods for automatically characterizing the functional identity
> of cells, and their associated properties, can be used to uncover processes
> involved in lineage differentiation as well as sub-typing cancer cells.
> They can also be used to suggest personalized therapies based on molecular
> signatures associated with pathology.
>
> In this talk, I will introduce a method that I have recently developed,
> called Archetypal-analysis for cell type identificaTION (ACTION), to infer
> the functional identity of cells from their transcriptional profile,
> classify them based on their principal functions, and reconstruct
> regulatory networks that are responsible for mediating their identity.
> Results from using ACTION to sub-type cancer cells in Melanoma patients
> reveal novel biomarkers along with their underlying regulatory networks.
>
>
> Host: Jinbo Xu <jinbo.xu at gmail.com>
>
>
>
>
> Mary C. Marre
> Administrative Assistant
> *Toyota Technological Institute*
> *6045 S. Kenwood Avenue*
> *Room 504*
> *Chicago, IL  60637*
> *p:(773) 834-1757 <(773)%20834-1757>*
> *f: (773) 357-6970 <(773)%20357-6970>*
> *mmarre at ttic.edu <mmarre at ttic.edu>*
>
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