[Colloquium] TTIC Colloquium: Yuan Ji, MD; University of Chicago, Northshore Hospital

[Mary Marre]

When:     Monday, June 22nd at 11:00 a.m.

Where:    TTIC, 6045 S Kenwood Avenue, 5th Floor, Room 526

Who:      Yuan Ji, MD; University of Chicago; Northshore Hospital

Title:       Zodiac — A comprehensive depiction of genetic interactions in
cancer by integrating TCGA data


Abstract:

The Cancer Genomes Atlas (TCGA) data are unique in that multimodal
measurements across genomics features, such as copy number, DNA
methylation, and gene expression, are obtained on matched tumor samples.
The multimodality provides an unprecedented opportunity to investigate the
interplay of these features. Graphical models are powerful tools for this
task that address the interaction of any two features in the presence of
others, while traditional correlation- or regression-based models cannot.
We introduce Zodiac, an online resource consisting of a large database
containing nearly 200 million interaction networks of multiple genomics
features produced by applying novel Bayesian graphical models on TCGA data
through massively parallel computation. Setting a new way of integrating
TCGA data, Zodiac, publically available at www.compgenome.org/ZODIAC, is
expected to facilitate the generation of new knowledge and hypotheses by
the community.


Host: Jinbo Xu





Mary C. Marre
Administrative Assistant
*Toyota Technological Institute*
*6045 S. Kenwood Avenue*
*Room 504*
*Chicago, IL  60637*
*p:(773) 834-1757*
*f: (773) 357-6970*
*mmarre at ttic.edu <mmarre at ttic.edu>*
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