[Colloquium] Reminder: Kurban/Dissertation Defense/Apr 22, 2011

[Margaret Jaffey]

A reminder about Gulriz's defense tomorrow.

       Department of Computer Science/The University of Chicago

                     *** Dissertation Defense ***


Candidate:  Gulriz Kurban

Date:  Friday, April 22, 2011

Time:  10:30 AM

Place:  Ryerson 251

Title: Computational Analysis of Protein Modular Domain Architectures

Abstract:
This dissertation presents novel computational methods to identify
domains in multi-domain protein sequences. These methods predict a
protein's modular domain architecture (MDA) from its local alignments
with a large set of proteins that contain one or more homologous
domains. The first method builds a probabilistic model that partitions
the protein positions into domains based on observed alignments,
giving us a preliminary prediction for the protein's MDA. The second
method incorporates the likelihood of switching between domains to
improve the prediction accuracy. It extends the initial model to take
into account the linker propensities for individual amino acids in
each position and the adjacency of the positions.

The end product of my research is a tool that facilitates further
experimental and computational analyses that require the preliminary
knowledge of protein domain positions, such as protein structure
determination and functional annotation.

Gulriz's advisor is Prof. Stuart Kurtz

Login to the Computer Science Department website for details,
including a draft copy of the dissertation:

 https://www.cs.uchicago.edu/phd/phd_announcements#gulriz

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Margaret P. Jaffey            margaret at cs.uchicago.edu
Department of Computer Science
Student Support Rep (Ry 156)               (773) 702-6011
The University of Chicago      http://www.cs.uchicago.edu
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