[Colloquium] Bruce R. Donald on November 10th, 2004

[Margery Ishmael]

DEPARTMENT OF COMPUTER SCIENCE

Date: Wednesday, November 10, 2004
Time: 2:30 p.m.
Place: Ryerson 251

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Speaker:  BRUCE R. DONALD

From:  Dartmouth College

Url:  http://www.cs.dartmouth.edu/brd/

Title: Algorithmic Challenges in Structural Molecular Biology and 
Proteomics

Abstract:

Some of the most challenging and influential opportunities for Physical 
Geometric Algorithms (PGA) arise in developing and applying information 
technology to understand the molecular machinery of the cell. Our 
recent work (and work by others) shows that many PGA techniques may be 
fruitfully applied to the challenges of computational molecular 
biology. PGA research may lead to computer systems and algorithms that 
are useful in structural molecular biology, proteomics, and rational 
drug design.

Concomitantly, a wealth of interesting computational problems arise in 
proposed methods for discovering new pharmaceuticals. In this talk, 
I'll discuss some recent results from my lab, including new algorithms 
for interpreting X-ray crystallography and NMR (nuclear magnetic 
resonance) data, disease classification using mass spectrometry of 
human serum, and protein redesign. Our algorithms have recently been 
used, respectively, to reveal the enzymatic architecture of organisms 
high on the CDC bioterrorism watch-list, for probabilistic cancer 
classification from human peripheral blood, and to redesign an 
antibiotic-producing enzyme to bind a novel substrate. I'll overview 
these projects, and survey some of the algorithmic and computational 
challenges.

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Host: Prof. ANNE ROGERS

*Refreshments will follow the talk in Ryerson 255*

People in need of assistance should call 773-834-8977 in advance.
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